解剖学报 ›› 2013, Vol. 44 ›› Issue (3 ): 437-440.doi: 10.3969/j.issn.0529-1356.2013.03.029

• 综述 • 上一篇    

三阴性乳腺癌干细胞微球体的治疗

赵乐1 梁晨2 李倩2 裴晓华3   

  1. 1.北京中医药大学2011级研究生中医外科专业; 2.2010级研究生中医外科专业,北京 00029; 3.北京中医药大学第三附属医院科教处,北京 100029
  • 收稿日期:2012-12-14 修回日期:2013-01-09 出版日期:2013-06-06 发布日期:2013-07-16
  • 通讯作者: 裴晓华 E-mail:pxh_127@163.com

Therapeutic research on triple negative breast cancer stem cell mammospheres

ZHAO Le LIANG Chen2  LI Qian2  PEI Xiao-hua 3*   

  1. 1. 2011 Graduate student, Surgery of Chinese Medicine; 2. 2010 Graduate Student, Surgery of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; 3. Department of Science and Education, the Third Affiliated Hospital of Beijing University of Chinese Medicine, Bejing  100029, China
  • Received:2012-12-14 Revised:2013-01-09 Online:2013-06-06 Published:2013-07-16

摘要:

三阴性乳腺癌(TNBC)是指雌激素受体(ER)、孕激素受体(PR)及人类表皮生长因子受体2 (HER-2)均为阴性的乳腺癌。TNBC恶性程度高,
侵袭性强,易远处转移,预后差,对内分泌治疗及靶向治疗的效果均欠佳,是临床治疗的难点。近几年研究发现,三阴性乳腺癌的发生、发展
很可能与其中的乳腺癌干细胞有关,乳腺癌干细胞微球体培养是一种收集干细胞的方法,被广泛用于三阴性乳腺癌的干细胞研究。

关键词: 三阴性乳腺癌, 乳腺癌干细胞, 微球体

Abstract:

Triple negative breast cancer(TNBC)is characterized by estrogen receptor(ER) negative, progesteronereceptor(PR)
negative, and human epidermal growth factorreceptor-2(HER-2) negative histochemical staining. TNBC has the features of high
malignant degree, strong invasion, prone to distant metastasis and poor prognosis. The endocrine therapy and targeted therapy
are generally not satisfied. Finding a effective treatment is a key point in clinical research. Recent studies have shown that
occur rence and development progress of TNBC may be related to breast cancer stem cells. Mammosphere culture is a very good
method of collection of breast cancer stem cells, and is used very widely in stem cells of TNBC.

Key words: Triple negative breast cancer, Breast cancer stem cells, Mammospheres.